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Intranasal Lidocaine for Treatment of Migraine:A Randomized, Double-Blind, Controlled Trial JAMA 276:319-321, Maizels,M.,et al, 1996 See this aricle in Pubmed Article Abstract Of 53 patients who received intranasal lidocaine,29(55%)had at least a 50% reduction of headache compared with 6(21%)of 28 controls(P=.004).Nausea and photophobia were significant reduced(P=.03 and P=.001,respectively). Rescue medication for headache relief was needed in 15(28%)of 53 patients in the lidocaine group vs 20(71%)of 28 controls.Among those with initial relief of headache,relapse of headache occurred in 10(42%)of 24 in the lidocaine group vs 5(83%)of 6 in the control group,usually within the first hour after treatment.Intranasal lidocaine provides rapid relief of headache in approximately 55%of ambulatory patients with migraine.Relapse of headache is common and occurs early after treatment.

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(click to filter results - removes previous filter) headache,treatment of intranasal medication lidocaine lidocaine,intranasal migraine migraine,treatment of treatment of neurologic disorder

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